Drag queens Anthony (Hugo Weaving, The Lord of the Rings trilogy) and Adam (Guy Pearce, HBO's Mare of Easttown, Prometheus) and a transgender woman, Bernadette (Terence Stamp), agree to perform a drag show at a resort in the remote Australian desert. As they head west from Sydney aboard their colorful bus, Priscilla, the three friends come to the forefront of a comedy of errors, encountering a number of strange characters, homophobic locals, all while widening comfort zones and finding new horizons.